Effect of Bay Leaf Extract (Syzygium polyanthum) on Blood Glucose, Malondialdehyde, and Insulin Levels in Animal Models of Diabetes: A Systematic Review
DOI:
https://doi.org/10.58258/rehat.v6i2.10008Keywords:
Syzygium Polyanthum (Daun Salam), Diabetes (Glukosa Darah), Malondialdehid, Insulin, Systematic Review.Abstract
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia resulting from impaired insulin secretion or action. Long-term antidiabetic therapy may cause adverse effects, highlighting the need for safer alternative treatments. Syzygium polyanthum (bay leaf) contains various bioactive compounds with antidiabetic and antioxidant activities. This study aimed to evaluate the effects of Syzygium polyanthum leaf extract on blood glucose, malondialdehyde (MDA) and insulin levels in diabetic rat models through a systematic review. This review was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Literature searches were performed in PubMed, Scopus, ScienceDirect, and Google Scholar. Included studies were experimental in vivo studies using diabetic rat models that assessed the effects of Syzygium polyanthum extract on blood glucose, insulin, and/or MDA levels. Risk of bias was evaluated using the CAMARADES tool. The results showed that administration of Syzygium polyanthum extract at doses of 250–500 mg/kg body weight consistently reduced blood glucose levels, accompanied by increased insulin levels and decreased MDA levels. These findings indicate that Syzygium polyanthum leaf extract has potential antidiabetic and antioxidant effects in animal models of diabetesReferences
Hadiyanti, H., Rahmat, D., & Chaidir, C. (2023). Nanoparticle standardized extract of bay leaves (Syzygium polyanthum) in lowering blood glucose of Rattus norvegicus. Jurnal Ilmiah Farmasi
Bahari, 14(1), 96–111. https://doi.org/10.52434/jfb.v14i1.1980
Harefa, H. E. E., Ginting, A. N. B., Meutia, R., & Simanjuntak, N. J. P. (2025). Activity test of salam extract on diabetic rats. Jurnal Sains Farmasi dan Kesehatan, 3(1), 1–7. https://doi.org/10.62379/jfkes.v3i1.2609
Hayati, L., & Hidayat, R. (2020). Effect of bay leaf extract on GLUT4-mediated blood glucose regulation in alloxan-induced rats. Eureka Herba Indonesia, 1, 15–18. https://doi.org/10.37275/ehi.v1i1.4
Meldawati, T., Tionando, W. A., Wulandari, S., Doloksaribu, G. E., & Suhartomi. (2025). Liver protective effect of Indonesian bay leaf in alloxan-induced diabetic rats. Journal of Applied and Natural Science, 17, 1131–1136. https://doi.org/10.31018/jans.v17i3.6619
Nasution, P. R. (2022). Effectiveness of ethanol extract of bay leaves on glucose levels in glucose-induced rats. Sains Medika, 1, 123–129. https://doi.org/10.63004/snsmed.v1i2.147
Parisa, N., Tamzil, N. S., Harahap, D. H., Prasasty, G. D., Hidayat, R., Maritska, Z., & Prananjaya, B. A. (2019). Bay leaf extract for diabetes therapy in Wistar rats. Journal of Physics Conference Series, 1246, 012034. https://doi.org/10.1088/1742-6596/1246/1/012034
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