Association of Body Mass Index with The Risk Of Gout Arthritis in Male and Female with Underweight, Normal Weight, Overweight, Obese

Slamet Raharjo; Olivia Andiana

doi:10.58258/jime.v8i2.3035

Association of Body Mass Index with The Risk Of Gout Arthritis in Male and Female with Underweight, Normal Weight, Overweight, Obese

Slamet Raharjo, Olivia Andiana

Abstract

The current study aims to analyze the correlation between body mass index (BMI) in underweight, normal weight, overweight, obese with the risk of gout arthritis in male and female adolescents in Malang. We conduct a correlational with a cross-sectional study approach. A total of 101 adolescents consisting of 59 men and 42 women, aged 16 – 23 years, with body mass index in categories underweight, normal weight, overweight, and obese are participated in this study. Uric acid levels were measured using Easy Touch (Easy Touch, Hsinchu, Taiwan) with a concentration unit of mg/dL, while BMI was calculated by dividing body weight (BW) (kg) with body height (BH) (m²). Pearson's correlation coefficient was used to analyze the correlation between BMI and uric acid levels. The results showed that the mean BMI was underweight (17.64 ± 0.26 kg/m²), normal weight (21.94 ± 1.33 kg/m²), overweight (25.81 ± 0.51 kg/m²), obese (29.92 ± 2.80 kg/m²), and levels of uric acid (6.09 ± 1.61 mg/dL) with (r = 0.838; p ≤ 0.001). Based on the results of the study, it was concluded that there was a positive correlation between BMI and uric acid levels. BMI showed a strong positive correlation with uric acid levels

Keywords

Body mass index; gout arthritis; uric acid; hyperuricemia; adolescents

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References

Anggraini E., Dewi Ari P., Novayelinda R. (2018). Faktor-Faktor Yang Berhubungan Dengan Kejadian Gout Arthritis Masyarakat Melayu. JOM FKp, 5(2), 683-692.

Almatsier, S. (2006). Penuntun Diet. Jakarta: Penerbit PT Gramedia Pustaka Utama.

Az-zahra, F., Nurwahid, D., & Pangastuti, R. (2014). Pola makan, obesitas, dan frekuensi serangan pada pasien artritis gout. Jurnal Gizi Klinik Indonesia, 11(1), 12-19.

Benn, C. L., Dua, P., Gurrell, R., Loudon, P., Pike, A., Storer, R. I., & Vangjeli, C. (2018). Physiology of Hyperuricemia and Urate-Lowering Treatments. Frontiers in medicine, 5, 160. https://doi.org/10.3389/fmed.2018.00160.

Bilotta, K.A.J. (2012). Kapita selekta penyakit: dengan implikasi keperawatan,ed 2. Jakarta: EGC

Budiono, A., Manampiring, A. E., & Bodhi, W. (2016). Hubungan kadar asam urat dengan status gizi pada remaja di Kecamatan Bolangitang Barat Kabupaten Bolaang Mongondow Utara. Jurnal e-Biomedik, 4(2).

Butler, F., Alghubayshi, A., & Roman, Y. (2021). The Epidemiology and Genetics of Hyperuricemia and Gout across Major Racial Groups: A Literature Review and Population Genetics Secondary Database Analysis. Journal of personalized medicine, 11(3), 231. https://doi.org/10.3390/jpm11030231.

Chen, J. H., Wen, C. P., Wu, S. B., Lan, J. L., Tsai, M. K., Tai, Y. P., Lee, J. H., Hsu, C. C., Tsao, C. K., Wai, J. P., Chiang, P. H., Pan, W. H., & Hsiung, C. A. (2015). Attenuating the mortality risk of high serum uric acid: the role of physical activity underused. Annals of the rheumatic diseases, 74(11), 2034–2042. https://doi.org/10.1136/annrheumdis-2014-205312.

Choi, H. K., Mount, D. B., Reginato, A. M., American College of Physicians, & American Physiological Society (2005). Pathogenesis of gout. Annals of internal medicine, 143(7), 499–516. https://doi.org/10.7326/0003-4819-143-7-200510040-00009.

Dalbeth, Nicola & Allan, Jordyn & Gamble, Gregory & Horne, Anne & Woodward, Owen & Stamp, Lisa & Merriman, Tony. (2020). Effect of body mass index on serum urate and renal uric acid handling responses to an oral inosine load: experimental intervention study in healthy volunteers. Arthritis Research & Therapy. 22. https://doi.org/10.1186/s13075-020-02357-y.

de Oliveira, E. P., & Burini, R. C. (2012). High plasma uric acid concentration: causes and consequences. Diabetology & metabolic syndrome, 4, 12. https://doi.org/10.1186/1758-5996-4-12.

Desai, R. J., Franklin, J. M., Spoendlin-Allen, J., Solomon, D. H., Danaei, G., & Kim, S. C. (2018). An evaluation of longitudinal changes in serum uric acid levels and associated risk of cardio-metabolic events and renal function decline in gout. PloS one, 13(2), e0193622. https://doi.org/10.1371/journal.pone.0193622.

Dewi, A. P & Asnita, L. (2016). Buku Ajar Perawatan Lansia Penderita Nyeri Sendi Dalam Keluarga dan Masyarakat. Pekanbaru: UR Press.

García-Esquinas, E., & Rodríguez-Artalejo, F. (2018). Association between serum uric acid concentrations and grip strength: Is there effect modification by age?. Clinical nutrition (Edinburgh, Scotland), 37(2), 566–572. https://doi.org/10.1016/j.clnu.2017.01.008.

Huda, N., Hossain, S., Rahman, M., Karim, M. R., Islam, K., Al Mamun, A., & Arefin, A. (2014). Elevated levels of plasma uric acid and its relation to hypertension in arsenic-endemic human individuals in Bangladesh. Toxicology and applied pharmacology, 281(1), 11-18.

Jaliana, J., & Suhadi, S. (2018). Faktor-Faktor yang Berhubungan dengan Kejadian Asam Urat pada Usia 20-44 Tahun di RSUD Bahteramas Provinsi Sulawesi Tenggara Tahun 2017. Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat, 3(2).

Juraschek, S. P., Miller, E. R., 3rd, & Gelber, A. C. (2013). Body mass index, obesity, and prevalent gout in the United States in 1988-1994 and 2007-2010. Arthritis care & research, 65(1), 127–132. https://doi.org/10.1002/acr.21791.

Kanwar, G., & Kabra, R. 2016. Serum uric acid level and obesity: An association. International Journal of healthcare Sciences, 4(1), 52-55

Kusumayanti, D.G.A., Wiardani NK, Antarini NAA. (2015). Pola konsumsi purin dan kegemukan sebagai faktor risiko hiperurisemia pada msyarakat Kota Denpasar. Jurnal Skala Husada, 12(1), 27 – 31.

Lee, J., Lee, J. Y., Lee, J. H., Jung, S. M., Suh, Y. S., Koh, J. H., & Park, S. H. (2015). Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study. Arthritis research & therapy, 17(1), 79.

Lingga, L. 2012. Bebas penyakit asam urat tanpa obat. Jakarta: PT. Agro Media Pusaka.

Martillo, M. A., Nazzal, L., & Crittenden, D. B. (2014). The crystallization of monosodium urate. Current rheumatology reports, 16(2), 400. https://doi.org/10.1007/s11926-013-0400-9.

Masheb, R. M., Lutes, L. D., Kim, H. M., Holleman, R. G., Goodrich, D. E., Janney, C. A., Kirsh, S., Richardson, C. R., & Damschroder, L. J. (2015). High-frequency binge eating predicts weight gain among veterans receiving behavioral weight loss treatments. Obesity (Silver Spring, Md.), 23(1), 54–61. https://doi.org/10.1002/oby.20931.

McAdams DeMarco, M. A., Maynard, J. W., Huizinga, M. M., Baer, A. N., Köttgen, A., Gelber, A. C., & Coresh, J. 2011. Obesity and younger age at gout onset in a community‐based cohort. Arthritis care & research, 63(8), 1108-1114.

Nasrul, S.E. (2012). Hiperurisemia pada Pra Diabetes. Jurnal Kesehatan Andalas, 1(2): 86-90. https://doi.org/10.25077/jka.v1i2.49.

Nishida, Y., Iyadomi, M., Higaki, Y., Tanaka, H., Hara, M., & Tanaka, K. 2011. Influence of physical activity intensity and aerobic fitness on the anthropometric index and serum uric acid concentration in people with obesity. Internal medicine, 50(19), 2121-2128.

Parfitt, Ekkekakis, P& Petruzzello, S. J. (2011). The pleasure and displeasure people feel when they exercise at different intensities. Sports medicine, 41(8), 641-671.

Perez-Ruiz, F., Dalbeth, N., & Bardin, T. (2015). A review of uric acid, crystal deposition disease, and gout. Advances in therapy, 32(1), 31–41. https://doi.org/10.1007/s12325-014-0175-z.

Roddy, E., & Doherty, M. 2010. Gout. Epidemiology of gout. Arthritis research & therapy, 12(6), 223.

Rosdiana, D. S., Khomsan, A., & Dwiriani, C. M. (2018). Pengetahuan Asam Urat, Asupan Purin Dan Status Gizi Terhadap Kejadian Hiperurisemia Pada Masyarakat Perdesaan. Media Pendidikan, Gizi, dan Kuliner, 7(2).

Sari, Y.N.I., & Syamsiyah, N.. (2017). Berdamai dengan asam urat. Jakarta: Bumi Medika.

Singh, J. A., Ramachandaran, R., Yu, S., Yang, S., Xie, F., Yun, H., Zhang, J., & Curtis, J. R. (2017). Is gout a risk equivalent to diabetes for stroke and myocardial infarction? A retrospective claims database study. Arthritis research & therapy, 19(1), 228. https://doi.org/10.1186/s13075-017-1427-5.

Skoczyńska, M., Chowaniec, M., Szymczak, A., Langner-Hetmańczuk, A., Maciążek-Chyra, B., & Wiland, P. (2020). Pathophysiology of hyperuricemia and its clinical significance - a narrative review. Reumatologia, 58(5), 312–323. https://doi.org/10.5114/reum.2020.100140.

Soeroso, J & Algristian, H. (2011). Asam urat. Jakarta: Niaga Swadaya. Diperoleh tanggal 20 Maret 2018 dari https://books.google.co.id/books.

Suiraoka. (2012). Penyakit Degeneratif. Yogyakarta: Nuha Medika.

Sustrani L., Alam S., & Hadibroto. (2007). Asam Urat. Jakarta: PT Gramedia Pustaka Utama.

Syarifuddin, L. A., Taiyeb, A. M., & Caronge, M. W. (2019). Hubungan Pola Makan dan Aktivitas Fisik dengan Kadar Asam Urat Dalam Darah Pada Penderita Asam Urat (Gout) di Wilayah Kerja Puskesmas Sabbangparu Kabupaten Wajo. In Seminar Nasional Biologi.

Tanaka, K., Ogata, S., Tanaka, H., Omura, K., Honda, C., Osaka Twin Research Group, & Hayakawa, K. (2015). The relationship between body mass index and uric acid: a study on Japanese adult twins. Environmental health and preventive medicine, 20(5), 347–353. https://doi.org/10.1007/s12199-015-0473-3.

Wang, H., Wang, L., Xie, R., Dai, W., Gao, C., Shen, P., Huang, X., Zhang, F., Yang, X., & Ji, G. (2014). Association of Serum Uric Acid with Body Mass Index: A Cross-Sectional Study from Jiangsu Province, China. Iranian journal of public health, 43(11), 1503–1509.

Wurangian, V. G. (2014). Gambaran Asam Urat Pada Remaja Obes Di Kabupaten Minahasa. Jurnal e-Biomedik, 2(1). https://doi.org/10.35790/ebm.v2i1.4019.

Zhu, Y., Pandya, B. J., & Choi, H. K. (2011). Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis and rheumatism, 63(10), 3136–3141. https://doi.org/10.1002/art.30520.

Zhu, Y., Zhang, Y., & Choi, H. K. (2010). The serum urate-lowering impact of weight loss among men with a high cardiovascular risk profile: the Multiple Risk Factor Intervention Trial. Rheumatology (Oxford, England), 49(12), 2391–2399. https://doi.org/10.1093/rheumatology/keq256.

DOI: http://dx.doi.org/10.58258/jime.v8i2.3035