UJI EFEKTIVITAS ANTIOKSIDANT (IC50) DAN TOKSISITAS AKUT (LD50) FRAKSI ETANOL DAUN NANGKA (Artocarpus Heterophyllus Lam.)

Recta Olivia Umboro, Dedent Eka Bimmaharyanto S, Ni Komang Wijiani Yanti

Abstract


Antioxidants are needed by the body to ward of free radicals from internal and external factors. The presence of free radicals is related to human helath conditions. Back to nature lifestyle and the high cost of drugs therapy makes people preferring to use traditional medicine. Jackfruit (Artocarpus heterophyllus Lam) leaves is contain several secondary metabolites such a flavanoids, alkaloids, sapaonins, steroids and tannins. Flavanoid have an antioxidant effect.In this study, the antioxidant activity of ethanol jackfruit (Artocarpus heterophyllus Lam) leaves extract was tested using 1,1-diphenyl-2-picrylhidrazyl (DPPH) method by UV-Vis Spectrophotometry, wich Vitamin C as comparison standart. Acute toxicity test was carried out by giving oral doses of ethanol jackfruit leaf extract to 4 groups of male rats. Group I as a control (aquadest);II(100mg/30gBW);III (150mg/30gBW); IV (200mg/30gBW) were then observed for 7 days.The antioxidant activity test showed that ethanol jackfruit (Artocarpus heterophyllus Lam) leaves extract had effectiveness as an antioxidant with an IC50 value of 58.58 ppm. The data were analyzed using one-way ANOVA showing sig value 0.228, which means (P>0.005), then followed by post hoc test, an average value of 0.00,probability value is 1.000 (sig>0.005). It can be concluded that there is no significant difference between the control and the treatment dose of 100mg, and there is a significant difference in the 150mg/30gBW, 200mg/30gBW dose groups. LD50 value dosage range in 150mg and 200mg.


Keywords


Jackfruits leaf, antioxidant, IC50, toxicity test, LD50

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References


Anonim, 2000, Parameter Standar Umum Ekstrak Tumbuhan Obat,1,3, Direktorat Jendral Pengawasan Obat Dan Makanan Departemen Kesehatan Republik Indonesia, Jakarta.

Asmaliani, ira., Lwo, Maria Immaculata. 2016. Uji Aktivitas Antiinflamasi Dari Ekstrak Metanol Daun Nangka (Artocarpus Heterophyllus Lam) Terhadap Tikus yang Diinduksi Karagenan Lambda.,. Fakultas farmasi UMI Makasar dan ITB.

Departemen Kesehatan Republik Indonesia. (1995). Farmakope Indonesia edisi IV. Jakarta: Departemen Kesehatan Republik Indonesia

Departemen Kesehatan Republik Indonesia. (2000). Parameter Standar Umum Ekstrak Tumbuhan Obat. Jakarta: Departemen Kesehatan Republik Indonesia.

DiPasquale LC, Hayes AW. 2001. Acute Toxicity and Eye Irritancy in Principles and Methods of Toxicology.4th Ed. Philadelphia:Taylor and Francis

Donatus, I.A. 2005. Toksikologi Dasar, Laboatorium Farmakologi dan Toksikologi, Fakultas Farmasi, UGM, Yogyakarta

Dyta, P.S., 2011, Uji Aktivitas Antibakteri Ekstrak Etanol Daun Nangka (artocarpus heterophyllus) terhadap Bakteri Staphyllococcus aureus dan Pseudomonas aeruginosa, Skripsi, Universitas Sebelas Maret, Surakarta

Gordon, M.H 1990. The mechanism of antioxidants action in vitro. Didalam :

B.J.F Hudson, editor. Food Antioxidants. Elsivier Applied Science, London.

Hanani, E, A. Mun`im, R. Sekarini, 2005, Identifikasi Senyawa Antioksidan Dalam Spons Callyspongia SP Dari Kepulauan Seribu, Majalah Ilmu Kefarmasian, Vol II, No 3.

Handajani. (2010). Gizi dan penyakit degeneratif. Makasar: FKM UNHAS Hidayat, A.Aziz Alimul, 2010. Metode Penelitian Kesehatan Paradigma Kuantitatif, Surabaya: Penerbit Health Books Publishing.

Holistic Health Solution. (2011). Khasiat Fantastis Kulit Manggis. Grasindo, Jakarta : 17-71

Katzung, Bertram G. 2004. Farmakologi Dasar dan Klinik, Buku ke 3 Edisi 8, Jakarta: Penerbit Salemba Medika

Marianne, Yuandani, dan Rosnani, 2011, Antidiabetic Activity From Ethanol Extract Of Kluwih’s Leaf (Artocarpus Camansi), Jurnal Natural, 11 (2): 64-68

Murray R.K., Granner D.K., and Rodwell V.W., 2009, Biokimia Harper, Diterjemahkan Oleh Andri Hartono, Edisi 27, Penerbit Buku Kedokteran, EGC, Jakarta

Ozyurt, D, 2005, Determination Of Total Antioxidant Capacity By a New Spectrophotometric Method Based On Ce (IV) Reducing Capacity measurement, Diakses Tanggal 18 Mei 2010.

Parwata, I Made Oka Adi. 2015. Antioksidan, Bahan Ajar Uji Bioaktivitas. Kimia Terapan Program Pasca Sarjana Universitas Udayana.

Pinnell, SR. 2003. Cutaneous Photodamage, Oxidative Stress, and Topical Antioxidant Protection. J Am Acad Dermatol. Vol 48. 1-19.

Priyanto. 2010. Toksikologi Ed: 2. Depok: Leskonfi Lembaga Studi dan Konsultasi Farmakologi.

Ramadhan, P., 2015, Mengenal Antioksidan, Cetakan Pertama, Graha Ilmu, Yogyakarta




DOI: http://dx.doi.org/10.58258/jupe.v5i6.2349

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